Tranexamic Acid and Total Knee Arthroplasty
نویسنده
چکیده
Total knee arthroplasty (TKA) is one of the most commonly performed elective orthopaedic procedures in the United States [1]. By 2030, the number is estimated to grow by 673% to 3.48 million TKAs performed a year [1]. TKA provides significant pain relief and improvement in quality of life [2]. However TKA surgery is not without complications. Of note is the risk of bleeding and requirement for transfusion. TKA surgery has been shown to have significant blood loss that sometimes requires blood transfusions [3-5]. Bleeding during total knee arthroplasty can be from different factors such as patient characteristics (hemophiliac, anticoagulation, cirrhosis, etc.) and surgical technique (bone cuts, soft tissues dissection, blood vessel injury). In some studies, transfusion rate after TKA has been as high as 30% [4]. Transfusion of blood products is not a benign procedure and is associated with many possible risks such as infection, acute systemic reactions, and death [6]. Transfusions also increase rehabilitation time and lengthen hospital stay and cost for the patient and payers [7,8]. Therefore, controlling blood loss during and after surgery is an important goal in order to achieve good results in TKA. One such method is to use tranexamic acid during TKA surgery.
منابع مشابه
Which Route of Tranexamic Acid Administration is More Effective to Reduce Blood Loss Following Total Knee Arthroplasty?
Background: The most appropriate route of tranexamic acid administration is controversial. In the current study, we compared the efficacy of intravenous (IV) and topical intra-articular tranexamic acid in reducing blood loss and transfusion rate in patients who underwent primary total knee arthroplasty. Methods: One hundred twenty 120 patients were scheduled to undergo primary total knee arth...
متن کاملIntraarticular Administration of Tranexamic Acid Following Total Knee Arthroplasty: A Case-control Study
Background: Tranexamic acid (TXA) has received extensive attention in management of blood loss in orthopedic surgeries. However, the ideal method of TXA administration is still controversial. This study aims to determine whether intraarticular injection of TXA reduces blood loss after total knee arthroplasty (TKA). Methods: Through a retrospective case-control study consecutive TKA patients...
متن کاملIntra-articular versus Intravenous Tranexamic Acid in Total Knee Arthroplasty: A Randomized Clinical Trial
Background: Total knee arthroplasty (TKA) can cause excessive blood loss requiring allogenic transfusions.Tranexamic acid (TXA) has been increasingly used for lowering blood loss. The present study aimed to comparethe efficacy of intravenous (IV) and intra-articular (IA) administrations of TXA in TKA patients who receive aspirin aschemoprophylaxis and uses no drain post-operat...
متن کاملThe Efficacy of Intravenous Versus Topical Use of Tranexamic Acid in Reducing Blood Loss after Primary Total Knee Arthroplasty: A Randomized Clinical Trial
Background: Blood loss during and immediately after total knee arthroplasty (TKA) is among the most challenging concerns. It has been demonstrated that Tranexamic acid (TXA) can help to reduce perioperative blood loss. TXA can be used as an oral, topical or intravenous injection. Many studies evaluated the effectiveness of each route of administration but few works on a comparison between them....
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Despite improvements in surgical and anesthetic techniques, total joint arthroplasty (TJA) is still associated with substantial blood loss and postoperative anemia (1). A considerable portion of patients with postoperative anemia require blood transfusion, which has been shown to negatively affect the outcome of TJA and predisposes patients to development of surgical site infection and peripr...
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